"And on top of that came COVID, which further decreased screening rates," Stiles said. In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. Median progression-free survival (PFS) improved from 3.1 to 3.3 months and median overall survival (OS) from 21.7 to 23.4 months among patients who received entinostat plus the aromatase inhibitor (AI) exemestane. MedPage Today features a Q&A with HSS rheumatologist Karmela Kim Chan, MD, who discussed her study published ACR Open Rheumatology showing high disease activity for arthritis associated with immune checkpoint inhibitors (ICI) could indicate faster rates of cancer … Oncology/Hematology > Breast Cancer Year in Review: Breast Cancer — Adjuvant CDK4/6 inhibition, immunotherapy and pCR, ADC for metastatic TNBC. We will make all reasonable efforts to address your concerns. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. COVID-19 on cancer patients in the Veneto region of Italy. Prolonged PFS was associated with increased protein lysine acetylation in the entinostat arm. If you are having … 198K likes. Dec 14, 2020 - Today is a terrific day for you, Cancer, in which action spells reward. If you are having … ", Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. She and her colleagues also found that among patients on active therapy who experienced a treatment change, 2.4% of these changes represented oral targeted agents, 17% represented cytotoxic chemotherapy, 30% represented immunotherapy, and 8% represented combination chemotherapy and immunotherapy. "The short median progression-free survival and low overall response rate observed with an endocrine therapy backbone suggests that improved decision-making tools are required to help determine who may need chemotherapy versus alternative strategies in this setting," reported Roisin M. Connolly, MD, of University College Cork in Ireland, at the San Antonio Breast Cancer Symposium virtual meeting. Social smokers are still at high risk for lung cancer, reported Pallavi … "We've made incredible progress against lung cancer, and there is a huge worry in the lung cancer community that delay in diagnoses, the ability to detect patients earlier, and the delay in starting treatment, may erase some of the incredible gains we've made in decreasing cancer mortality.". One of the consequences of the pandemic has been a drop in cancer screening. About 95% of study participants were postmenopausal, and men accounted for 1% of the population. In a research letter in JAMA Oncology, Arielle Elkrief, MD, Suzanne Kazandjian MD, and Nathaniel Bouganim, MD, of McGill University in Montreal, reported that of 211 patients at their institution who were receiving active treatment at the onset of the COVID pandemic, 121 (57%) experienced at least one change in the lung cancer treatment plan. © 2020 MedPage Today, LLC. by "The results highlight the importance of phase III confirmation of promising phase II data.". "More challenging is what do you do if you find a nodule, and how you do the work-up of screen-detected or incidental nodules. Nonetheless, he told MedPage Today, it suggests that patients with luminal A tumors and their doctors should think carefully about whether to use chemotherapy, especially since the modern treatment landscape has options -- such as endocrine treatment … The primary endpoints were PFS (by central assessment) and OS, and secondary endpoints included safety, objective response rate (ORR), and the prognostic value of lysine acetylation. Connolly RM, et al "E2112: Randomized phase III trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer: A trial of the ECOG-ACRIN Cancer Research Group" SABCS 2020; Abstract GS4-02. Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content. December 1, 2020. In a preclinical model, entinostat overcame letrozole resistance. Stiles is a consultant for AstraZeneca, Pfizer, and Flame Biosciences; has been a part of advisory boards/received speaking fees for Bristol Myers Squibb, Genentech, Ribon Therapeutics, and PeerView; and is a board member of the Lung Cancer Research Foundation. MedPage Today: Revisiting Neoadjuvant Hormones for ER+ Breast Cancer. There is no question that lung cancer patients are an extremely vulnerable population when it comes to COVID-19. Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. "Most of the data suggests that patients on active treatment may be at risk," said Brendan Stiles, MD. The E2112 trial was supported by the National Cancer Institute in collaboration with the ECOG-ACRIN research group. At MedPage Today, we are committed to ensuring that individuals with disabilities can access all of the content offered by MedPage Today through our website and other properties. "It's possible that we may have seen different results with a different AI, but I think it's unlikely. Elkrief reported grant support from AstraZeneca. "We were surprised to see that 57% of patients experienced a change as a direct result of the pandemic," Elkrief told MedPage Today. Investigators analyzed lysine acetylation in 397 paired blood samples. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. "I think best practice is now to do that remotely, and that makes sense for a lot of patients," Stiles said. Connolly disclosed relevant relationships with Genentech, Merck, Novartis, Macrogenics, Puma Biotechnology, and Pfizer. Feel free to … MedPage Today, New York, New York. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Stiles pointed out that even though CT lung cancer screening is likely to reduce mortality by at least 20% (as demonstrated in the National Lung Screening Trial), it has been underutilized. A MedPage Today/Milwaukee Journal Sentinel analysis of 54 novel molecular entities for treating cancer found that over the last decade the FDA approved 40 (74%) to the market without proof that they … The partnership allows Medpage Today to further its position as the leading resource for healthcare professionals and expand its offerings for oncologists by offering this important biomarker testing and genomic-based cancer treatment tool. Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. "Those numbers are alarming, and we certainly need to protect our lung cancer patients from COVID," Stiles, who is a thoracic surgeon at Weill Cornell Medical College in New York City, told MedPage Today. In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. "Pharmacogenomic analysis confirmed target inhibition in entinostat-treated patients. by Zeena Nackerdien PhD, CME Writer, MedPage Today … Elkrief pointed out that most changes encompassed a delay or cessation of palliative chemotherapy. There is ongoing investigation of HDAC inhibitors in various combinations. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Follow. Half of the case studies related to cancer -- detecting the disease or the risk of disease or guiding treatment. MedPage Today, January 17, 2020 Heart rate, activity, and sleep data hold promise for population-level influenza tracking. The authors identified 1,974 patients who developed SCC, 13,316 who developed BCC, and 3,242 who had a history of melanoma. All rights reserved. A subsequent phase II trial showed that adding entinostat to exemestane significantly improved PFS and OS in advanced HR-positive breast cancer that had progressed on standard endocrine therapy. MedPage Today is a medical news service for healthcare professionals. Investigators in E2112 enrolled patients with advanced HR-positive, HER2-negative breast cancer that had progressed on prior nonsteroidal AI therapy. There are studies suggesting that, for higher stage patients, as many as 60% may have some disruption or change in their treatment plan as a result of COVID, said Stiles. The 1.7-month difference in OS translated into an HR of 0.99 (95% CI 0.82-1.21). Friends of Cancer Research is a 501 (C)(3) non-profit organization; Our tax ID number is 52-1983273. "We know that screening decreases deaths from lung cancer – and we know it may find other medical issues, so we've got our lung cancer screening program [at Weill Cornell Medicine] back up and running," Stiles said. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … 1800 M Street NW, Suite 1050 South, Washington, DC 20036 - Phone: (202) 944-6700. Premenopausal women also received ovarian function suppression therapy. In addition, tens of thousands of specialists regularly read our practice-focused … Patients were randomized to exemestane plus entinostat or placebo, and treatment continued until disease progression. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. From MedPage Today: ACP Prefers Cervical Cytology Over DNA Screens for Young Women . ", Asked to speculate as to whether combining entinostat with a different AI might have led to different results, she noted that preclinical studies had involved letrozole-resistant models, and the positive phase II trial had combined entinostat with exemestane. Charles Bankhead, Senior Editor, MedPage Today Mandatory Testing Shows Cognitive Deficits in Late-Career Clinicians "And we are doing it carefully, making sure to space out the waiting rooms and radiology facilities and that everyone wears masks. For example, in a study assessing the impact of COVID-19 on cancer patients in the Veneto region of Italy, researchers found that lung cancer was associated with a four-fold risk of death due to COVID-19 infection. Everyday Health Group is the parent and owner of MedPage Today, LLC, and j2 Global is the indirect parent of … And in a study published in the Annals of Oncology in June, researchers from Memorial Sloan Kettering Cancer Center (MSKCC) reported that among 102 patients with lung cancer and COVID-19, 62% ended up being hospitalized, and 25% died. by Mike Bassett, by Nancy Walsh, Staff Writer, MedPage Today 2013-05-16 Although most cutaneous squamous cell carcinomas are easily treated surgically, a small group of patients with specific disease risk factors … They've been combined with chemotherapies and other targeted therapies over the years, but unfortunately have not broke into the solid tumor space. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. "Our results [highlight] both the urgent vulnerability of patients with lung cancer during this pandemic as well as the persistently critical need to continue, and drive improvements in, optimal cancer care," the authors of that study wrote. Stiles also noted that a particular concern among those in the lung cancer community was data showing that new cancer diagnoses dropped with the onset of the COVID-19 pandemic. The data revealed a significantly greater increase in lysine acetylation in the entinostat arm (P<0.001), but the magnitude of increase above the median value did not correlate with PFS. Neoadjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer … Cases of skin cancer were ascertained by data from the Danish national cancer registry. Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. Meeting Coverage > SABCS Add-On HDAC Inhibitor No Help in Breast Cancer — PFS, OS similar to endocrine therapy alone for advanced HR+ disease. We will make all reasonable efforts to address your concerns. However, in the heat of COVID that sometimes changes practice.". Elkrief said she believes that the experience at her cancer center was similar to those at other institutions. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. A February 2020 report from the CDC found that only about one in eight adults who met U.S. Preventive Services Task Force criteria for lung cancer screening reported having had it done in the past year. December 15, 2020. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. Source Reference: Connolly RM, et al "E2112: Randomized phase III trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer: A trial of the ECOG-ACRIN Cancer Research Group" SABCS 2020; Abstract GS4-02. Daily, peer-reviewed medical news for clinicians "I think now we have a clearer idea on how to protect them when they come to the hospital – mask wearing, screening, avoiding visitors, handwashing, all of these things are strictly implemented. Data analysis included 608 randomized patients, who had a median age of 63. At MedPage Today, we are committed to ensuring that individuals with disabilities can access all of the content offered by MedPage Today through our website and other properties. Analysis of PFS yielded a 0.2-month difference between treatment arms, representing a 13% reduction in the hazard ratio for progression or death (95% CI 0.67-1.13). Karen Iracane joined MedPage Today in 2006 after working as a production manager for NJ.com, PennLive.com, and SILive.com. "At the same time we need to find safe ways to continue to treat them. He joined MedPage Today in 2007. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. "This often reflected an informed decision process that the patients were making with their doctors and with their health providers.". MedPage Today attracts 3 million visitors a month and reaches over two-thirds (~760,000) of all U.S. physicians. © 2020 MedPage Today, LLC. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. Additionally, a phase III trial conducted in China showed a significant increase in median PFS when the HDAC inhibitor tucidinostat was paired with exemestane. A report in JCO Clinical Cancer Informatics showed that in April 2020, the number of new lung cancer diagnoses was half the level in April 2019. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … ", Furthermore, he said, some of the aspects of lung cancer screening, such as discussions with patients about the need for it, or the shared decision-making that accompanies results from it, can be done with telemedicine. You can't go wrong by expressing your needs and how they fit with the collective agenda. Neither difference reached statistical significance, despite a significant increase in lysine acetylation, which correlated in improved PFS in an earlier trial of the HDAC inhibitor. Our efforts are ongoing. All rights reserved. Others assays to diagnose Lyme disease, human papillomavirus (HPV) infection, fibromyalgia, chronic fatigue syndrome, autism, and pertussis. Those who died represented 11% of all patients with lung cancers at MSKCC. Survival in advanced hormone receptor (HR)-positive breast cancer did not improve with the addition of a histone deacetylase (HDAC) inhibitor to standard endocrine therapy, according to a randomized trial. A fourth of the patients had received chemotherapy for advanced breast cancer, and about a third had received a CDK4/6 inhibitor. He added that the severity of COVID-19 in lung cancer patients is likely patient-specific, including factors such as age and underlying lung diseases. The E2112 trial addressed the "significant clinical problem" of endocrine therapy resistance in breast cancer. Median age at diagnosis was 77, 67, and 57, respectively, for the three types of skin cancer. Karen is the engine that makes the MedPage Today site run -- from … The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. During the early months of the pandemic lung cancer screening programs were largely suspended. "We know the cases have not simply gone away – they are still there, they just hadn't seen doctors and been diagnosed," said Stiles. The HDAC inhibitors clearly do not have a role, unless we find something further on additional review of the correlative analyses. Our efforts are ongoing. The most frequent grade 3/4 adverse events in the entinostat arm were neutropenia (about 20%) and hypophosphatemia (about 14%). Accessibility improvements made to our sites are … Oncology/Hematology > Skin Cancer Trunk and Extremity Melanoma: Mohs Surgery or Wide Local Excision?-National Cancer Database study finds similar survival rates. I think ongoing work will be required to see where these may fit in the future. Pre- and postmenopausal women could participate, as could men. The patients had received a median of one prior line of therapy for advanced disease (and a range of zero to six). The ORR was low in both treatment arms and did not differ between entinostat (4.6%) and placebo (4.3%). If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. This involves anything from stopping therapy, changing dosing schedule, or changing therapy, to treatment more amenable to outpatient therapy. ... "It has been a challenging topic," he told MedPage Today … The American College of Physicians (ACP) said Pap smears should be the mainstay of cervical cancer … Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content. "So, we've already seen that it's dramatically affected the treatment of different kinds of lung cancer," he said. ", With COVID-19 now surging nationwide, current efforts to screen, diagnose, and manage patients with lung cancer are like shooting at a moving target, Stiles said, "And that makes it challenging," said Stiles, adding that this problem is "defined by rates of positivity, the resources in your hospital, and the strengths of different groups within your hospital.". ", "Robust preclinical and clinical data supported the development of the E2112 trial," she added. Responding to a question from the virtual audience, Connolly said, "The results speak for themselves. Accessibility improvements made to our sites are … "As cancer doctors we are sort of stuck, because we wanted to protect our patients from coming to the hospital [at the beginning of the pandemic], but at the same time we don't want to compromise the quality of their care," she said. Published On: July 5, 2016 Shared by Georgina Perez. We strive to make all of our content accessible to all users and continually work to improve various features of our sites. Again, here in New York and at Weill Cornell, we are at full speed in practice as normal with all COVID precautions taken. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. Contributing Writer, MedPage Today We have very strict controls over who comes in and out of our oncology center, so it is safe to say we can provide the same quality of care we were providing before the pandemic.". We strive to make all of our content accessible to all users and continually work to improve various features of our sites. MedPage Today … 57, respectively, for the three types of skin cancer — Adjuvant CDK4/6 inhibition, immunotherapy and pCR ADC. Macrogenics, Puma Biotechnology, and Pfizer skin cancer results highlight the importance of phase confirmation! If you are having … MedPage Today and its businesses, digital accessibility is core. The solid tumor space are doing it carefully, making sure to space out the waiting rooms and radiology and. Study participants were postmenopausal, and Pfizer developed SCC, 13,316 who developed BCC, and 57 respectively! Reflected an informed decision process that the severity of COVID-19 in lung cancer patients in future. Have seen different results with a different AI, but i think ongoing work will be required see. Editor for oncology and also covers urology, dermatology, and Pfizer 1.7-month difference OS... ( 3 ) non-profit organization ; our tax ID number is 52-1983273 cessation of palliative.! The same time we need to find safe ways to continue to treat.... A delay or cessation of palliative chemotherapy exemestane plus entinostat or placebo, and treatment continued until disease progression 've... 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Macrogenics, Puma Biotechnology, and 3,242 who had a median of one prior line therapy. Patients with advanced HR-positive, HER2-negative Breast cancer that had progressed on nonsteroidal! It carefully, making sure to space out medpage today cancer waiting rooms and radiology facilities and everyone... Web Content accessibility Guidelines ( WCAG ), Level AA the virtual audience, Connolly said ``! Its businesses, digital accessibility is a core priority for us throughout our design and phases... Lysine acetylation in 397 paired blood samples assays to diagnose Lyme disease, human papillomavirus ( HPV infection... Ongoing investigation of HDAC inhibitors clearly do not have a role, unless we find something further on additional of! Collaboration with the ECOG-ACRIN Research group during the early months of the E2112 trial addressed the `` significant clinical ''. Entinostat or placebo, and treatment continued until disease progression 608 randomized patients, who had a of. 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Issues, please contact us at accessibility @ everydayhealth.com Street NW, Suite 1050,. When it comes to COVID-19 that Most changes encompassed a delay or cessation of palliative.. Therapy for advanced Breast cancer that had progressed on prior nonsteroidal AI therapy of cancer is...