Loss of renal function is not only considered to be part of the aging process itself but also reflects the multimorbidity of many geriatric patients. -, J Ren Nutr. Our findings also suggest possible demographic and clinical characteristics to target for limiting the rate of change in renal function in older adults treated for hypertension. In fact, it has been reported to be –3.5 mL•min•y −1 in 180 elderly patients (age 67 y) with CKD (stages 3–4) [8] . (1994) The Italian Longitudinal Study on Aging (ILSA): design and methods. Effect of annual change in renal function on all-cause and cardiovascular mortality in relation to those with stable renal function. We are indebted to the participants, family practitioners, study staffs, data management centers, and Second Australian National Blood Pressure (ANBP2) Management Committee. These factors may well explain the more likely rapid reduction in GFR in the older subgroup. Our review highlights the current literature focusing on the functional and oncological outcome of surgically treated renal cancer in elderly patients. Reid, L.J. At 30-month follow-up, the observed decline in renal function was greater among patients treated with warfarin compared with dabigatran (Pradaxa, Boehringer Ingelheim). Kidney transplantation remains the treatment of choice for ESRD in elderly patients, providing a survival advantage and better quality of life when compared with dialysis . The proportion of people with anemia was 11.8%. Glomerular filtration rates (eGFRs) were estimated at baseline and at 11-year follow-up. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Reduced kidney function as a risk factor for incident heart failure: The atherosclerosis risk in communities (ARIC) study. We also observed that higher pulse pressure at baseline was associated with a decline in renal function. A rapid increase in eGFRs was observed in those who were younger, women, having higher total and HDL cholesterol concentrations, and having a lower eGFR at baseline (Table 2). Hypertension and CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES), 1999-2004. Although some observational studies have shown a protective effect of BP lowering on hypertension-related deterioration of renal function (13–15), some randomized controlled trials have shown no such effect (16–18). These findings highlighted the importance of observing the rate of change in renal function rather than absolute renal function status because the adjusted results in our study showed that a rapid annual decline in eGFR independently predicted a higher risk of all-cause and cardiovascular mortality, whereas using just the last eGFR measure during the in-trial period showed no such relationship. African American Study of Kidney Disease and Hypertension Study Group. We also observed that higher pulse pressure at baseline was associated with a decline in renal function. In our study, the elderly patients kept under regular surveillance in the nephrology clinic tended to have more advanced renal impairment and were more likely to have a rapid decline in kidney function. The underlying pathophysiology could be caused by reduced renal perfusion and therefore overall renal function because of lower BP, which has been observed in animal studies (36). The mean age was 58.6 (8.8) years, and 46.2% of participants were male. Renal impairment associated with diabetes in the elderly. Chronic Kidney Disease Epidemiology Collaboration. 13. The presence of proteinuria increases the morbidity and mortality induced by a decreased GFR. During the in-trial period of our study, over a median of 4 years, we observed an average 0.55 ml/min per 1.73 m2 decline in eGFR annually among the study participants. We observed that achieving an in-trial average target BP <140/90 mmHg was associated with a rapid decline in renal function. Clinical practice guidelines for the management of hypertension in the community a statement by the American Society of Hypertension and the International Society of Hypertension. J Am Soc Nephrol 1991; 2:856. Lancet. The age-related decline in renal function is one of the better known aspects of normal ageing, although its mechanism in both histological and physiological terms is not understood (McLachan 1978). Renal disease in the elderly. Nephron Physiol 2011; 119 Suppl 1:p6. Lithium use in elderly tied to significant decline of renal function, finds study . Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? Our findings in older adults with hypertension indicate that a more rapid decline is independently associated with a greater chance of both all-cause and cardiovascular mortality. Menon, V, Katz, R, Mukamal, K et al. Adiponectin is not associated with renal function decline in community-dwelling elderly adults. The ANBP2 study was approved by the Ethics Committee of the Royal Australian College of General Practitioners and conducted according to the Helsinki Declaration of the World Medical Association. Design, setting, participants, & measurements Data from the Second Australian National Blood Pressure study were used, where 6083 hypertensive participants aged ≥65 years were enrolled during 1995–1997 and followed for a median of 4.1 years (in-trial). Kidney Problems. N2 - Aim: The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. However, those who experienced a rapid increase in eGFRs showed a trend to a protective effect (statistically not significant) from subsequent all-cause and cardiovascular mortality compared with those whose eGFRs remained stable (Table 3). Beilin, M.A. However, from the available data we did not observe any differences in treatment adherence between the ACEI-based and thiazide diuretic–based treatment group. A large Kindred objective: we tested the hypothesis that impaired kidney function the post-trial period improvement renal. 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